Direct measurement of the lumped constant for 2-deoxy-[1-C]glucose in vivo in human skeletal muscle
نویسندگان
چکیده
TAPIO UTRIAINEN, STEFANIA LOVISATTI, SARI MÄKIMATTILA, ALESSANDRA BERTOLDO, SUSAN WEINTRAUB, RALPH DEFRONZO, CLAUDIO COBELLI, AND HANNELE YKI-JÄRVINEN Division of Diabetology, Department of Medicine, University of Helsinki, FIN-00029 HUCH, Helsinki, Finland; Department of Electronics and Informatics, University of Padova, 35131 Padua, Italy; and The University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229
منابع مشابه
Direct measurement of the lumped constant for 2-deoxy-[1-(14)C]glucose in vivo in human skeletal muscle.
The lumped constant (LC) is used to convert the clearance rate of 2-deoxy-D-glucose (2-DG(CR)) to that of glucose (Glc(CR)). There are currently no data to validate the widely used assumption of an LC of 1.0 for human skeletal muscle. We determined the LC for 2-deoxy-[1-(14)C]glucose (2-DG) in 18 normal male subjects (age, 29+/- 2 yr; body mass index, 24.8+/-0.8 kg/m(2)) after an overnight fast...
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